La seguridad del paciente es un tema fundamental en la atención de la salud a nivel mundial, con repercusiones para los enfermeros, médicos, administradores y, lo que es más importante, para los pacientes y su bienestar. Future research should identify obstacles to course completion, explore participants' awareness of patient safety issues and perceived need for more instruction, and look at ways to disseminate the course to the broadest international population of nurses and nursing students. Limitations of the study include the lack of a comparison group, disparity in the number of participants across the course's language formats (English, Portuguese, Spanish), and the large number of participants who registered for but did not complete the course. Most participants who completed the Nursing and Patient Safety ODL course reported being satisfied with the course content and experience, and demonstrated increased knowledge on patient safety, as measured by post-module quizzes and self-report. The study's objectives are to describe the implementation of an international ODL program to enhance patient safety knowledge in nurses and nursing students, and to examine the participants' assessments of this online approach as an effective learning tool. This article reports on an online Nursing and Patient Safety course developed in 2012 by the University of Miami School of Nursing and Health Studies in conjunction with the Pan American Health Organization and the International Network for Nursing and Patient Safety. Online distance learning (ODL) is widely accepted among most disciplines in higher education and has been used to promote patient safety knowledge among health care students and professionals in diverse contexts. Patient safety is a critical topic in health care globally, with implications for nurses, physicians, administrators, and most importantly, patients and their well-being. 7 School of Nursing School of Nursing University of North Carolina at Chapel Hill Chapel HillNC United States of America School of Nursing, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States of America.6 Facultad de Enfermería Facultad de Enfermería Pontificia Universidad Católica del Ecuador Quito Ecuador Facultad de Enfermería, Pontificia Universidad Católica del Ecuador, Quito, Ecuador.5 Health Systems and Services Health Systems and Services Pan American Health Organization/World Health Organization WashingtonDC United States of America Health Systems and Services, Pan American Health Organization/World Health Organization, Washington, DC, United States of America.4 Escuela de Enfermería Escuela de Enfermería Universidad Nacional de Rosario Rosario Argentina Escuela de Enfermería, Universidad Nacional de Rosario, Rosario, Argentina.3 Escuela Nacional de Enfermería y Obstetricia Escuela Nacional de Enfermería y Obstetricia Universidad Nacional Autónoma de México Mexico City Mexico Escuela Nacional de Enfermería y Obstetricia, Universidad Nacional Autónoma de México, Mexico City, Mexico.2 Escuela de Enfermería Escuela de Enfermería Universidad Nacional de Córdoba Córdoba Argentina Escuela de Enfermería, Universidad Nacional de Córdoba, Córdoba, Argentina.1 University of Miami School of Nursing and Health Studies University of Miami School of Nursing and Health Studies MiamiFL United States of America University of Miami School of Nursing and Health Studies, Miami, FL, United States of America.